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Asthma Clinical Research Network (ACRN)
This study has been completed.
Sponsored by: National Heart, Lung, and Blood Institute (NHLBI)
Information provided by: National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier: NCT00000577
  Purpose

This study will establish a network of interactive asthma clinical research groups to evaluate current therapies, new therapies, and management strategies for adult asthma.


Condition Intervention Phase
Asthma
Lung Diseases
 Drug: Albuterol
Drug: Colchicine
Drug: Adrenal Cortex Hormones
Drug: Adrenergic-Beta Agonists
 Phase III

MedlinePlus related topics: Asthma
Drug Information available for: Corticosteroids Albuterol sulfate Albuterol Levalbuterol hydrochloride Levalbuterol tartrate Colchicine Epinephrine Epinephrine bitartrate
U.S. FDA Resources
Study Type:
Interventional
Study Design:
Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment
Official Title:
Asthma Clinical Research Network (ACRN)

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date:
September 1993
Estimated Study Completion Date:
July 2008

  Show Detailed Description

  Eligibility
Ages Eligible for Study:
18 Years to 75 Years
Genders Eligible for Study:
Both
Accepts Healthy Volunteers:
No
Criteria

Patients with asthma; specific eligibility criteria vary for each study.

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00000577

Locations
United States, California
University of California, San Francisco
San Francisco, California, United States, 94143
University of California at San Diego
La Jolla, California, United States, 92103
United States, Colorado
National Jewish Medical & Research Center
Denver, Colorado, United States, 80206
United States, Massachusetts
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
United States, Missouri
Washington University
St. Louis, Missouri, United States, 63110
United States, North Carolina
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27103
United States, Wisconsin
University of Wisconsin at Madison
Madison, Wisconsin, United States, 53792
Sponsors and Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
Investigators
Study Chair: Homer A. Boushey University of California, San Francisco
Study Chair: William Calhoun University of Pittsburgh at Pittsburgh
Study Chair: Mario Castro Washington University School of Medicine
Study Chair: Vernon Chinchilli Pennsylvania State University Hershey Medical Center
Study Chair: Elliot Israel Brigham and Women's Hospital
Study Chair: Robert F. Lemanske, Jr. University of Wisconsin at Madison
Study Chair: Richard J. Martin National Jewish Medical & Research Center
Study Chair: Stephen P. Peters Wake Forest University
Study Chair: Stephen I. Wasserman University of California, San Diego
  More Information

Study Home Page  This link exits the ClinicalTrials.gov site

Publications:
Kamada AK, Szefler SJ, Martin RJ, Boushey HA, Chinchilli VM, Drazen JM, Fish JE, Israel E, Lazarus SC, Lemanske RF. Issues in the use of inhaled glucocorticoids. The Asthma Clinical Research Network. Am J Respir Crit Care Med. 1996 Jun;153(6 Pt 1):1739-48. Review. No abstract available.
Irvin CG, Martin RJ, Chinchilli VM, Kunselman SJ, Cherniack RM. Quality control of peak flow meters for multicenter clinical trials. The Asthma Clinical Research Network (ACRN). Am J Respir Crit Care Med. 1997 Aug;156(2 Pt 1):396-402.
Martin RJ, Wanger JS, Irvin CG, Bucher Bartelson B, Cherniack RM. Methacholine challenge testing: safety of low starting FEV1. Asthma Clinical Research Network (ACRN). Chest. 1997 Jul;112(1):53-6.
Fish JE, Peters SP, Chambers CV, McGeady SJ, Epstein KR, Boushey HA, Cherniack RM, Chinchilli VM, Drazen JM, Fahy JV, Hurd SS, Israel E, Lazarus SC, Lemanske RF, Martin RJ, Mauger EA, Sorkness C, Szefler SJ. An evaluation of colchicine as an alternative to inhaled corticosteriods in moderate asthma. National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. Am J Respir Crit Care Med. 1997 Oct;156(4 Pt 1):1165-71.
Martin RJ, Pak J, Kunselman SJ, Cherniack RM. Assessment of the AirWatch lung function monitoring system.Asthma Clinical Research Network (ACRN). J Allergy Clin Immunol. 1999 Mar;103(3 Pt 1):535-6. No abstract available.
Drazen JM, Israel E, Boushey HA, Chinchilli VM, Fahy JV, Fish JE, Lazarus SC, Lemanske RF, Martin RJ, Peters SP, Sorkness C, Szefler SJ. Comparison of regularly scheduled with as-needed use of albuterol in mild asthma. Asthma Clinical Research Network. N Engl J Med. 1996 Sep 19;335(12):841-7.
Leone FT, Mauger EA, Peters SP, Chinchilli VM, Fish JE, Boushey HA, Cherniack RM, Drazen JM, Fahy JV, Ford J, Israel E, Lazarus SC, Lemanske RF, Martin RJ, McGeady SJ, Sorkness C, Szefler SJ. The utility of peak flow, symptom scores, and beta-agonist use as outcome measures in asthma clinical research. Chest. 2001 Apr;119(4):1027-33.
Lemanske RF Jr, Sorkness CA, Mauger EA, Lazarus SC, Boushey HA, Fahy JV, Drazen JM, Chinchilli VM, Craig T, Fish JE, Ford JG, Israel E, Kraft M, Martin RJ, Nachman SA, Peters SP, Spahn JD, Szefler SJ. Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial. JAMA. 2001 May 23-30;285(20):2594-603.
Lazarus SC, Boushey HA, Fahy JV, Chinchilli VM, Lemanske RF Jr, Sorkness CA, Kraft M, Fish JE, Peters SP, Craig T, Drazen JM, Ford JG, Israel E, Martin RJ, Mauger EA, Nachman SA, Spahn JD, Szefler SJ. Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial. JAMA. 2001 May 23-30;285(20):2583-93.
Israel E, Drazen JM, Liggett SB, Boushey HA, Cherniack RM, Chinchilli VM, Cooper DM, Fahy JV, Fish JE, Ford JG, Kraft M, Kunselman S, Lazarus SC, Lemanske RF, Martin RJ, McLean DE, Peters SP, Silverman EK, Sorkness CA, Szefler SJ, Weiss ST, Yandava CN. The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. Am J Respir Crit Care Med. 2000 Jul;162(1):75-80.
Israel E, Drazen JM, Liggett SB, Boushey HA, Cherniack RM, Chinchilli VM, Cooper DM, Fahy JV, Fish JE, Ford JG, Kraft M, Kunselman S, Lazarus SC, Lemanske RF Jr, Martin RJ, McLean DE, Peters SP, Silverman EK, Sorkness CA, Szefler SJ, Weiss ST, Yandava CN. Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma. Int Arch Allergy Immunol. 2001 Jan-Mar;124(1-3):183-6.
Fahy JV, Boushey HA, Lazarus SC, Mauger EA, Cherniack RM, Chinchilli VM, Craig TJ, Drazen JM, Ford JG, Fish JE, Israel E, Kraft M, Lemanske RF, Martin RJ, McLean D, Peters SP, Sorkness C, Szefler SJ. Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study. Am J Respir Crit Care Med. 2001 May;163(6):1470-5.
King TS, Chinchilli VM and the Asthma Clinical Research Network:. Robust estimators of the concordance correlation coefficient. Joint Statistical Meetings, Page 50, August 2001.
Sorkness CA, Ford JG, Lemanske RF Jr. Recruitment strategies in the Asthma Clinical Research Network. Control Clin Trials. 2001 Dec;22(6 Suppl):222S-35S.
Martin RJ, Kephart DK, Dyer AM, Fahy J, Kraft M. Quality control within the Asthma Clinical Research Network. Control Clin Trials. 2001 Dec;22(6 Suppl):207S-21S.
Forand PE, Kunselman SJ, Drazen JM, Israel E, Pillari A, Armstrong TJ, Britton TB. Genetic analysis in the Asthma Clinical Research Network. Control Clin Trials. 2001 Dec;22(6 Suppl):196S-206S.
Kunselman SJ, Armstrong TJ, Britton TB, Forand PE. Implementing randomization procedures in the asthma clinical research network. Control Clin Trials. 2001 Dec;22(6 Suppl):181S-95S.
Pogash RM, Boehmer SJ, Forand PE, Dyer AM, Kunselman SJ. Data management procedures in the Asthma Clinical Research Network. Control Clin Trials. 2001 Dec;22(6 Suppl):168S-80S.
Hess HM, Curley RM, Chinchilli VM, Cherniack RM, Evans RL. Modem remote support of pulmonary-function testing and quality control systems. Control Clin Trials. 2001 Dec;22(6 Suppl):156S-67S.
Curley RM, Evans RL, Kaylor J, Pogash RM, Chinchilli VM. Development and deployment of an internet-based data management system for use by the Asthma Clinical Research Network. Control Clin Trials. 2001 Dec;22(6 Suppl):135S-55S.
Chinchilli VM, Drazen JM, Fish JE, Lemanske RF Jr, Lazarus SC, Martin RJ. The clinical trials in the initial five-year award period of the Asthma Clinical Research Network. Control Clin Trials. 2001 Dec;22(6 Suppl):126S-34S.
Kephart DK, Chinchilli VM, Hurd SS, Cherniack RM. The organization of the Asthma Clinical Research Network: a multicenter, multiprotocol clinical trials team. Control Clin Trials. 2001 Dec;22(6 Suppl):119S-25S.
Chinchilli VM. The Asthma Clinical Research Network. Control Clin Trials. 2001 Dec;22(6 Suppl):117S-8S. No abstract available.
Janson SL, Alioto ME, Boushey HA. Attrition and retention of ethnically diverse subjects in a multicenter randomized controlled research trial. Control Clin Trials. 2001 Dec;22(6 Suppl):236S-43S.
Mauger EA, Mauger DT, Fish JE, Chinchilli VM, Israel E. Summarizing methacholine challenges in clinical research. Control Clin Trials. 2001 Dec;22(6 Suppl):244S-51S.
Martin RJ, Szefler SJ, Chinchilli VM, Kraft M, Dolovich M, Boushey HA, Cherniack RM, Craig TJ, Drazen JM, Fagan JK, Fahy JV, Fish JE, Ford JG, Israel E, Kunselman SJ, Lazarus SC, Lemanske RF Jr, Peters SP, Sorkness CA. Systemic effect comparisons of six inhaled corticosteroid preparations. Am J Respir Crit Care Med. 2002 May 15;165(10):1377-83.
Szefler SJ, Martin RJ, King TS, Boushey HA, Cherniack RM, Chinchilli VM, Craig TJ, Dolovich M, Drazen JM, Fagan JK, Fahy JV, Fish JE, Ford JG, Israel E, Kiley J, Kraft M, Lazarus SC, Lemanske RF Jr, Mauger E, Peters SP, Sorkness CA. Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol. 2002 Mar;109(3):410-8.
McEntegart D. Implementing randomization procedures in the Asthma Clinical Research Network. Control Clin Trials. 2002 Aug;23(4):424-6; discussion 426-8. No abstract available.
Kraft M, Martin RJ, Lazarus SC, Fahy JV, Boushey HA, Lemanske RF Jr, Szefler SJ; Asthma Clinical Research Network. Airway tissue mast cells in persistent asthma: predictor of treatment failure when patients discontinue inhaled corticosteroids. Chest. 2003 Jul;124(1):42-50.
Burchard EG, Avila PC, Nazario S, Casal J, Torres A, Rodriguez-Santana JR, Toscano M, Sylvia JS, Alioto M, Salazar M, Gomez I, Fagan JK, Salas J, Lilly C, Matallana H, Ziv E, Castro R, Selman M, Chapela R, Sheppard D, Weiss ST, Ford JG, Boushey HA, Rodriguez-Cintron W, Drazen JM, Silverman EK; Genetics of Asthma in Latino Americans (GALA) Study. Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma. Am J Respir Crit Care Med. 2004 Feb 1;169(3):386-92. Epub 2003 Nov 14.
Lind DL, Choudhry S, Ung N, Ziv E, Avila PC, Salari K, Ha C, Lovins EG, Coyle NE, Nazario S, Casal J, Torres A, Rodriguez-Santana JR, Matallana H, Lilly CM, Salas J, Selman M, Boushey HA, Weiss ST, Chapela R, Ford JG, Rodriguez-Cintron W, Silverman EK, Sheppard D, Kwok PY, Gonzalez Burchard E. ADAM33 is not associated with asthma in Puerto Rican or Mexican populations. Am J Respir Crit Care Med. 2003 Dec 1;168(11):1312-6. Epub 2003 Sep 04.
Tantisira KG, Lake S, Silverman ES, Palmer LJ, Lazarus R, Silverman EK, Liggett SB, Gelfand EW, Rosenwasser LJ, Richter B, Israel E, Wechsler M, Gabriel S, Altshuler D, Lander E, Drazen J, Weiss ST. Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Hum Mol Genet. 2004 Jul 1;13(13):1353-9. Epub 2004 May 05.
Israel E, Chinchilli VM, Ford JG, Boushey HA, Cherniack R, Craig TJ, Deykin A, Fagan JK, Fahy JV, Fish J, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF Jr, Liggett SB, Martin RJ, Mitra N, Peters SP, Silverman E, Sorkness CA, Szefler SJ, Wechsler ME, Weiss ST, Drazen JM; National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet. 2004 Oct 23;364(9444):1505-12.
Deykin A, Lazarus SC, Fahy JV, Wechsler ME, Boushey HA, Chinchilli VM, Craig TJ, Dimango E, Kraft M, Leone F, Lemanske RF, Martin RJ, Pesola GR, Peters SP, Sorkness CA, Szefler SJ, Israel E. Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids. J Allergy Clin Immunol. 2005 Apr;115(4):720-7.
Boushey HA, Sorkness CA, King TS, Sullivan SD, Fahy JV, Lazarus SC, Chinchilli VM, Craig TJ, Dimango EA, Deykin A, Fagan JK, Fish JE, Ford JG, Kraft M, Lemanske RF Jr, Leone FT, Martin RJ, Mauger EA, Pesola GR, Peters SP, Rollings NJ, Szefler SJ, Wechsler ME, Israel E; National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. Daily versus as-needed corticosteroids for mild persistent asthma. N Engl J Med. 2005 Apr 14;352(15):1519-28.
Fabbri LM. Does mild persistent asthma require regular treatment? N Engl J Med. 2005 Apr 14;352(15):1589-91. No abstract available.

Study ID Numbers:
215, U10 HL51823, U10 HL51831, U10 HL51834, U10 HL51843, U10 HL51845, U10 HL56443, U10 HL74073, U10 HL74204, U10 HL74206, U10 HL74208, U10 HL74212, U10 HL74218, U10 HL74225, U10 HL74227, U10 HL74231, Y02 HL51810
First Received:
October 27, 1999
Last Updated:
August 24, 2006
ClinicalTrials.gov Identifier:
NCT00000577  
Health Authority:
United States: Federal Government

Study placed in the following topic categories:
Hypersensitivity
Lung Diseases, Obstructive
Respiratory Tract Diseases
Lung Diseases
Albuterol
Hypersensitivity, Immediate
Asthma
Colchicine
Epinephrine
Respiratory Hypersensitivity

Additional relevant MeSH terms:
Molecular Mechanisms of Pharmacological Action
Immune System Diseases
Bronchial Diseases
Antineoplastic Agents
Therapeutic Uses
Mitosis Modulators
Tubulin Modulators
Antimitotic Agents
Antirheumatic Agents
Gout Suppressants
Pharmacologic Actions

ClinicalTrials.gov processed this record on January 06, 2009



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